LEONI is a partner in the AMPLITUDE project for more efficient diagnosis and therapy of bladder cancer

EU funding programme develops laser-based imaging technique for medicine and biophotonics

Bladder carcinomas rank eleventh in cancer incidence. Early diagnosis and the right therapies are crucial for successful treatment. This is precisely where the EU-funded project AMPLITUDE (Advanced Multimodal Photonics Laser Imaging Tool for Urothelial Diagnosis in Urology) comes in. Laser-based imaging is intended to make cancer diagnosis and therapy more efficient and precise. LEONI is developing the novel endoscopic probe and supplying the high-performance quartz glass fibres for the system.

Already since the beginning of 2020, LEONI has been part of a multidisciplinary European research team developing a new medical imaging technique for diagnosing and monitoring bladder cancer therapy. This project, called AMPLITUDE, is a Photonics Public Private Partnership initiative and was funded by the European Union's Horizon 2020 research and innovation programme under grant agreement no. 871227.

The novel procedure will be used in the examination of bladder tissue in oncology. Bladder cancer should thus be identified earlier, progress in therapy should be easier to recognise and the healing process of the affected tissue should be easier to follow.

As a leading manufacturer of medical fibre-optic probes, LEONI is developing the endoscope for the procedure and integrating quartz glass fibres for different wavelengths needed for the innovative technology.

Innovative imaging and precision

To achieve its objective, AMPLITUDE uses a novel technology that has a penetration depth that is 3 times greater than previous methods, allowing tissue to be examined deep below the tissue surface.

The technology is based on high-contrast, high-resolution multiphoton imaging, in which the tissue is irradiated with different laser light. The light backscattered from the tissue is detected and can be evaluated spectroscopically in such a way that it is possible to distinguish directly between healthy and cancerous bladder tissue. The necessary laser systems are being newly developed within the project.

The laser light transmission to the tissue and the transmission of the backscatter signal are carried out using medically approved quartz glass fibres. This is where LEONI, as a leading supplier, shows its expertise and, in addition to the glass fibre assembly, develops a very compact endoscope for beam guidance within the human body.

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